Medicinal Chemistry

Scope Note: Medicinal Chemistry is a chemistry based discipline, also involving aspects of biological and pharmaceutical sciences. As defined, it is concerned with the invention, discovery, design, identification and preparation of biologically active compounds, the study of their metabolism, the interpretation of their mode of action at the molecular level and the construction of structure activity relationships.
Source: http://www.pharmacy.olemiss.edu/medicinal_chemistry/


  1. Design and Synthesis of Hydroxyethylene-Based BACE-1 Inhibitors Incorporating Extended P1 Substituents
    http://www.benthamscience.com/open/tomcj/articles/V007/1TOMCJ.pdf
  2. Tricyclic Pyrazoles. Part 5. Novel 1,4-Dihydroindeno[1,2-c]pyrazole CB2 Ligands Using Molecular Hybridization Based on Scaffold Hopping
    http://www.benthamscience.com/open/tomcj/articles/V006/1TOMCJ.pdf
  3. Virtual Screening for Finding Novel COX-2 Inhibitors as Antitumor Agents
    http://www.benthamscience.com/open/tomcj/articles/V006/15TOMCJ.pdf
  4. Identification of G-Quadruplex Inducers Usinga Simple, Inexpensiveand Rapid High Throughput Assay, and TheirInhibition of Human Telomerase
    http://www.benthamscience.com/open/tomcj/articles/V006/20TOMCJ.pdf
  5. ChemVassa: A New Method for Identifying Small Molecule Hits in Drug Discovery
    http://www.benthamscience.com/open/tomcj/articles/V006/29TOMCJ.pdf
  6. Drug Development to Protozoan Diseases
    http://www.benthamscience.com/open/tomcj/articles/V005/SI0001TOMCJ/1TOMCJ.pdf
  7. Current Developments in the Therapy of Protozoan Infections
    http://www.benthamscience.com/open/tomcj/articles/V005/SI0001TOMCJ/4TOMCJ.pdf
  8. Acridine and Acridinones: Old and New Structures with Antimalarial Activity
    http://www.benthamscience.com/open/tomcj/articles/V005/SI0001TOMCJ/11TOMCJ.pdf
  9. Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies
    http://www.benthamscience.com/open/tomcj/articles/V005/SI0001TOMCJ/21TOMCJ.pdf
  10. Structures, Targets and Recent Approaches in Anti-Leishmanial Drug Discovery and Development
    http://www.benthamscience.com/open/tomcj/articles/V005/SI0001TOMCJ/31TOMCJ.pdf
  11. HIV Protease Inhibitors: Effect on the Opportunistic Protozoan Parasites
    http://www.benthamscience.com/open/tomcj/articles/V005/SI0001TOMCJ/40TOMCJ.pdf
  12. Thiadiazine Derivatives as Antiprotozoal New Drugs
    http://www.benthamscience.com/open/tomcj/articles/V005/SI0001TOMCJ/51TOMCJ.pdf
  13. Kinetic Analysis of Some Chalcones and Synthetic Chalcone Analogues on the Fenton-Reaction Initiated Deoxyribose Degradation Assay
    http://www.benthamscience.com/open/tomcj/articles/V005/61TOMCJ.pdf
  14. Editorial: Medicinal Chemistry of Novel Anti-Diabetic Drugs
    http://www.benthamscience.com/open/tomcj/articles/V005/SI0068TOMCJ/68TOMCJ.pdf
  15. Medicinal Chemistry of the Anti-Diabetic Effects of Momordica Charantia: Active Constituents and Modes of Actions,.
    http://www.benthamscience.com/open/tomcj/articles/V005/SI0068TOMCJ/70TOMCJ.pdf
  16. Amylin Analogues in the Treatment of Diabetes Mellitus: Medicinal Chemistry and Structural Basis of its Function
    http://www.benthamscience.com/open/tomcj/articles/V005/SI0068TOMCJ/78TOMCJ.pdf
  17. Medicinal Chemistry and Applications of Incretins and DPP-4 Inhibitors in the Treatment of Type 2 Diabetes Mellitus
    http://www.benthamscience.com/open/tomcj/articles/V005/SI0068TOMCJ/82TOMCJ.pdf
  18. Medicinal Chemistry and Actions of Dual and Pan PPAR Modulators
    http://www.benthamscience.com/open/tomcj/articles/V005/SI0068TOMCJ/93TOMCJ.pdf
  19. A Single Amino Acid Substitution Makes WNK4 Susceptible to SB 203580 and SB 202190
    http://www.benthamscience.com/open/tomcj/articles/V004/57TOMCJ.pdf
  20. Editorial - Novel Therapeutic Drugs for Neuropsychiatric Disorders
    http://www.benthamscience.com/open/tomcj/articles/V004/SI0001TOMCJ/1TOMCJ.pdf
  21. The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors
    http://www.benthamscience.com/open/tomcj/articles/V004/SI0001TOMCJ/3TOMCJ.pdf
  22. Glycine Transport Inhibitors for the Treatment of Schizophrenia
    http://www.benthamscience.com/open/tomcj/articles/V004/SI0001TOMCJ/10TOMCJ.pdf
  23. Metabotropic Glutamate Receptors: Potential Drug Targets for Psychiatric Disorders
    http://www.benthamscience.com/open/tomcj/articles/V004/SI0001TOMCJ/20TOMCJ.pdf
  24. α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease.
    http://www.benthamscience.com/open/tomcj/articles/V004/SI0001TOMCJ/37TOMCJ.pdf
  25. Monitoring by HPLC of Chamomile Flavonoids Exposed to Rat Liver Microsomal Metabolism
    http://www.benthamscience.com/open/tomcj/articles/V003/1TOMCJ.pdf
  26. Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors
    http://www.benthamscience.com/open/tomcj/articles/V003/8TOMCJ.pdf
  27. Chronic Experimental Diabetes Accelerates Urinary Elimination of Deprenyl and its Metabolites
    http://www.benthamscience.com/open/tomcj/articles/V002/1TOMCJ.pdf
  28. Important Bioactive Molecules of Erythrocytes in Colorectal Cancer Patients After Colectomy
    http://www.benthamscience.com/open/tomcj/articles/V002/6TOMCJ.pdf
  29. A New Generation Prothrombin Time Method for INR
    http://www.benthamscience.com/open/tomcj/articles/V002/11TOMCJ.pdf
  30. Molecular Docking and Analysis of Survivin Delta-Ex3 Isoform Protein,
    http://www.benthamscience.com/open/tomcj/articles/V002/16TOMCJ.pdf
  31. Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction
    http://www.benthamscience.com/open/tomcj/articles/V002/21TOMCJ.pdf
  32. Cyclobutane-Containing Alkaloids: Origin, Synthesis, and Biological Activities
    http://www.benthamscience.com/open/tomcj/articles/V002/26TOMCJ.pdf
  33. Identification and Characterization of Skin Biomolecules for Drug Targeting and Monitoring by Vibrational Spectroscopy
    http://www.benthamscience.com/open/tomcj/articles/V002/38TOMCJ.pdf
  34. Cell Engineering and Molecular Pharming for Biopharmaceuticals
    http://www.benthamscience.com/open/tomcj/articles/V002/49TOMCJ.pdf
  35. A New Concept for Smart Drug Delivery: Adhesion Induced Nanovector Implosion
    http://www.benthamscience.com/open/tomcj/articles/V002/62TOMCJ.pdf
  36. Transcorneal Permeation in a Corneal Device of Non-Steroidal Anti-Inflammatory Drugs in Drug Delivery Systems
    http://www.benthamscience.com/open/tomcj/articles/V002/66TOMCJ.pdf
  37. A New Method for Radiosynthesis of 11C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [11C]GR103545
    http://www.benthamscience.com/open/tomcj/articles/V002/72TOMCJ.pdf
  38. The Investigation of Structure-Activity Relationships of Tacrine Analogues: Electronic-Topological Method
    http://www.benthamscience.com/open/tomcj/articles/V002/75TOMCJ.pdf
  39. Design of Anticancer Agents Utilizing Streptozocin for In Silico Optimization of Properties and Pattern Recognition Identification of Group Features
    http://www.benthamscience.com/open/tomcj/articles/V002/81TOMCJ.pdf
  40. Two- and Three-Dimensional Quantitative Structure-Activity Relationships Studies on a Series of Liver X Receptor Ligands
    http://www.benthamscience.com/open/tomcj/articles/V002/87TOMCJ.pdf
  41. The Utility of Oligopeptidase in Brain-Targeting Delivery of an Enkephalin Analogue by Prodrug Design
    http://www.benthamscience.com/open/tomcj/articles/V002/97TOMCJ.pdf
  42. Synthesis and Bronchodilator Studies of Some Novel 6-Alkyl/Aryl-1,2,4- Triazino[4,3-c]Quinazolines
    http://www.benthamscience.com/open/tomcj/articles/V002/101TOMCJ.pdf
  43. C4-Substituted Isoquinolines: Synthesis and Cytotoxic Action
    http://www.benthamscience.com/open/tomcj/articles/V001/1TOMCJ.pdf
  44. Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors
    http://www.benthamscience.com/open/tomcj/articles/V001/4TOMCJ.pdf
  45. Heteroarotinoids with Anti-Cancer Activity Against Ovarian Cancer Cells
    http://www.benthamscience.com/open/tomcj/articles/V001/11TOMCJ.pdf
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